Serotonin organelles of rabbit platelets contain synaptophysin
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چکیده
منابع مشابه
Human platelets contain brain-derived neurotrophic factor.
Neurotrophic support to peripheral sensory neurons is provided by 2 factors of related sequence, NGF and brain-derived neurotrophic factor (BDNF). NGF is present in peripheral target tissues, while BDNF has only been reported in the CNS. We now report the biological characterization and molecular cloning of a cDNA for BDNF from human platelets. BDNF in human platelets has biological activities ...
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Peptidylprolyl cis,trans-isomerase (PPIase) activity was detected in the cytosol, mitochondria, and chloroplast of pea plants. Cyclosporin A inhibited the activity largely localized to the mitochondrial matrix while rapamycin inhibited the PPIase activity associated with the mitochondrial membranes. Differential inhibition by the two immunosuppressive drugs, the specific binding of these drugs ...
متن کاملQuantal release of serotonin from platelets.
Even though platelets are known to play a critical role in hemostasis, mediated in part by their uptake, storage, and release of serotonin, there are many unexplored aspects of this process. Herein, single-cell amperometry is employed to characterize the dynamic secretion of serotonin from platelet dense-body granules. On the basis of a three-dimensional random walk simulation that estimates de...
متن کاملSerotonin-binding glycoprotein of rat platelets.
Platelets, because of their ability to take up serotonin, are often considered as models of serotonergic neurons. We have purified a glycoprotein from rat platelets that specifically binds serotonin (KD = 10 nM) but not [3H]imipramine (up to 0.2 microM). This protein is distinct from fibronectin. Antiserum raised against this protein was shown to be monospecific by double diffusion, rocket immu...
متن کاملSpectrophotofluorometry of serotonin in blood platelets.
A rapid sensitive, and reproducible assay for determination of platelet serotonin is reported. Serotonin in extracted into an ascorbic acid solution by freezing and thawing and sonication. Ascorbic acid stabilizes the serotonin in the extract, and added ethanol enhances the final fluorescence of serotonin, which is measured in a concentrated hydrochloric acid medium (activation at 295 nm and em...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1990
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1990.tb19475.x